Anti-KLRB1 antibody (73-140) (STJ116310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLRB1 (73-140) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLRB1 |
| Gene ID | 3820 |
| Uniprot ID | KLRB1_HUMAN |
| Immunogen Region | 73-140 |
| Immunogen Sequence | KCSVDIQQSRNKTTERPGLL NCPIYWQQLREKCLLFSHTV NPWNNSLADCSTKESSLLLI RDKDELIH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1). |
Additional Info
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1C-Type Lectin Domain Family 5 Member BHnkr-P1aNkr-P1aNatural Killer Cell Surface Protein P1aCd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibodyAnti-C-Type Lectin Domain Family 5 Member B antibodyAnti-Hnkr-P1a antibodyAnti-Nkr-P1a antibodyAnti-Natural Killer Cell Surface Protein P1a antibodyAnti-Cd Antigen Cd161 antibodyAnti-KLRB1 antibodyAnti-CLEC5B antibodyAnti-NKRP1A antibody |
Information sourced from Uniprot.org