• Western blot analysis of various lysates using KLRB1 Rabbit polyclonal antibody (STJ116310) at 1:3000 dilution. _Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. _Lysates/proteins: 25 Mu g per lane. _Blocking buffer: 3% nonfat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 90s.
  • Western blot analysis of lysates from rat liver, using KLRB1 Rabbit polyclonal antibody (STJ116310) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-KLRB1 antibody (73-140) (STJ116310)

SKU:
STJ116310

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KLRB1 (73-140) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KLRB1
Gene ID: 3820
Uniprot ID: KLRB1_HUMAN
Immunogen Region: 73-140
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1).
Immunogen Sequence: KCSVDIQQSRNKTTERPGLL NCPIYWQQLREKCLLFSHTV NPWNNSLADCSTKESSLLLI RDKDELIH
Tissue Specificity Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Protein Name Killer Cell Lectin-Like Receptor Subfamily B Member 1
C-Type Lectin Domain Family 5 Member B
Hnkr-P1a
Nkr-P1a
Natural Killer Cell Surface Protein P1a
Cd Antigen Cd161
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibody
Anti-C-Type Lectin Domain Family 5 Member B antibody
Anti-Hnkr-P1a antibody
Anti-Nkr-P1a antibody
Anti-Natural Killer Cell Surface Protein P1a antibody
Anti-Cd Antigen Cd161 antibody
Anti-KLRB1 antibody
Anti-CLEC5B antibody
Anti-NKRP1A antibody

Information sourced from Uniprot.org

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