Anti-KLK7 antibody (30-253) (STJ27457)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLK7 (30-253) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLK7 |
| Gene ID | 5650 |
| Uniprot ID | KLK7_HUMAN |
| Immunogen Region | 30-253 |
| Immunogen Sequence | IIDGAPCARGSHPWQVALLS GNQLHCGGVLVNERWVLTAA HCKMNEYTVHLGSDTLGDRR AQRIKASKSFRHPGYSTQTH VNDLMLVKLNSQARLSSMVK KVRLPSRCEPPGTTCTVSGW GTTTSPDVTFPSDLMCVDVK LISPQDCTKVYKDLLENSML CAGIPDSKKNACNGDSGGPL VCRGTLQGLVSWGTFPCGQP NDPGVYTQVCKFTKWINDTM KKHR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-253 of human KLK7 (NP_644806.1). |
Additional Info
| Tissue Specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). |
| Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. |
| Protein Name | Kallikrein-7Hk7Serine Protease 6Stratum Corneum Chymotryptic EnzymeHscce |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-9725554 |
| Cellular Localisation | SecretedIn Ovarian CarcinomaSecreted And Also Observed At The Apical Membrane And In Cytoplasm At The Invasive Front |
| Alternative Antibody Names | Anti-Kallikrein-7 antibodyAnti-Hk7 antibodyAnti-Serine Protease 6 antibodyAnti-Stratum Corneum Chymotryptic Enzyme antibodyAnti-Hscce antibodyAnti-KLK7 antibodyAnti-PRSS6 antibodyAnti-SCCE antibody |
Information sourced from Uniprot.org