Anti-KLHL2 antibody (521-571 aa) (STJ195080)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human KLHL2 at the amino acid range 521-571
General Information
| Short Description | Rabbit polyclonal anti-Kelch-like protein 2 (521-571 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLHL2 |
| Gene ID | 11275 |
| Uniprot ID | KLHL2_HUMAN |
| Immunogen | Synthesized peptide derived from the human KLHL2 at the amino acid range 521-571 |
| Immunogen Region | 521-571 aa |
| Specificity | This antibody detects endogenous levels of KLHL2 at Human/Mouse |
Additional Info
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation. The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. |
| Protein Name | Kelch-Like Protein 2Actin-Binding Protein Mayven |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffleLamellipodiumCytosolA Proportion Colocalizes With The Actin CytoskeletonWhen Over-ExpressedColocalizes With Nptxr In Perinuclear Aggresomes |
| Alternative Antibody Names | Anti-Kelch-Like Protein 2 antibodyAnti-Actin-Binding Protein Mayven antibodyAnti-KLHL2 antibody |
Information sourced from Uniprot.org