Anti-KLF10 antibody (161-365) (STJ115146)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLF10 (161-365) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLF10 |
| Gene ID | 7071 |
| Uniprot ID | KLF10_HUMAN |
| Immunogen Region | 161-365 |
| Immunogen Sequence | MKAASILNYQNNSFRRRTHL NVEAARKNIPCAAVSPNRSK CERNTVADVDEKASAALYDF SVPSSETVICRSQPAPVSPQ QKSVLVSPPAVSAGGVPPMP VICQMVPLPANNPVVTTVVP STPPSQPPAVCPPVVFMGTQ VPKGAVMFVVPQPVVQSSKP PVVSPNGTRLSPIAPAPGFS PSAAKVTPQIDSSRIRSHIC SHPGC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 161-365 of human KLF10 (NP_001027453.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock.binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation. |
| Protein Name | Krueppel-Like Factor 10Egr-AlphaTransforming Growth Factor-Beta-Inducible Early Growth Response Protein 1Tgfb-Inducible Early Growth Response Protein 1Tieg-1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 10 antibodyAnti-Egr-Alpha antibodyAnti-Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 antibodyAnti-Tgfb-Inducible Early Growth Response Protein 1 antibodyAnti-Tieg-1 antibodyAnti-KLF10 antibodyAnti-TIEG antibodyAnti-TIEG1 antibody |
Information sourced from Uniprot.org