Anti-KISS1R antibody (301-350 aa) (STJ93845)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KISS1R at the amino acid range 301-350
General Information
| Short Description | Rabbit polyclonal anti-KiSS-1 receptor (301-350 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:100-1:500ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KISS1R |
| Gene ID | 84634 |
| Uniprot ID | KISSR_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KISS1R at the amino acid range 301-350 |
| Immunogen Region | 301-350 aa |
| Specificity | KiSS-1R Polyclonal Antibody detects endogenous levels of KiSS-1R protein. |
Additional Info
| Function | Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. |
| Protein Name | Kiss-1 ReceptorKiss-1rG-Protein Coupled Receptor 54G-Protein Coupled Receptor Ot7t175Hot7t175Hypogonadotropin-1Kisspeptins ReceptorMetastin Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Kiss-1 Receptor antibodyAnti-Kiss-1r antibodyAnti-G-Protein Coupled Receptor 54 antibodyAnti-G-Protein Coupled Receptor Ot7t175 antibodyAnti-Hot7t175 antibodyAnti-Hypogonadotropin-1 antibodyAnti-Kisspeptins Receptor antibodyAnti-Metastin Receptor antibodyAnti-KISS1R antibodyAnti-AXOR12 antibodyAnti-GPR54 antibody |
Information sourced from Uniprot.org