Anti-KIR2DL1/KIR2DL3/KIR2DL4 antibody (44-202aa) [2H6] (STJA0041513)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human KIR2DL4 (44-202aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-KIR2DL1/KIR2DL3/KIR2DL4 (44-202aa) for use in ELISA and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2H6 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIR2DL4 |
| Gene ID | 3805 |
| Uniprot ID | KI2L4_HUMAN |
| Accession Number | NP_002246 |
| Immunogen | Recombinant human KIR2DL4 (44-202aa) purified from E. coli |
| Immunogen Region | 44-202aa |
Additional Info
| Tissue Specificity | Expressed in decidual NK cells and innate lymphoid cell type I (ILC1). Expressed in a subset of peripheral NK cells. |
| Function | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl4Cd158 Antigen-Like Family Member DG9pKiller Cell Inhibitory Receptor 103asKir-103asMhc Class I Nk Cell Receptor Kir103asCd Antigen Cd158d |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Killer Cell Immunoglobulin-Like Receptor 2dl4 antibodyAnti-Cd158 Antigen-Like Family Member D antibodyAnti-G9p antibodyAnti-Killer Cell Inhibitory Receptor 103as antibodyAnti-Kir-103as antibodyAnti-Mhc Class I Nk Cell Receptor Kir103as antibodyAnti-Cd Antigen Cd158d antibodyAnti-KIR2DL4 antibodyAnti-CD158D antibodyAnti-KIR103AS antibody |
Information sourced from Uniprot.org