Anti-Kip2 antibody [25B2] (STJ16101826)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenProkaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein.
General Information
| Short Description | Mouse monoclonal anti-p57 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 25B2 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | >=19 mg/L |
| Dilution Range | IHC-P 1:50 |
| Formulation | Tissue culture supernatant with sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Prokaryotic recombinant antigen corresponding to a 116 amino acid region of the N-terminus of the p57 protein. |
Additional Info
| Background | Cyclin-dependent kinases are positive regulators of cell proliferation. p57 protein acts as a tumor suppressor to counter this. It is closely related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumors and tumors associated with the Beckwith-Wiedermann syndrome. There is increasing interest in p57 as a marker in gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviors. |
Information sourced from Uniprot.org