Anti-KIM-1 antibody [10103] (STJ400245)

SKU:
STJ400245

Shipping:
Free Shipping
Current Stock:
Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-KIM-1 is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 10103
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Purification: Greater than 95% purity
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: Unspecified, storage at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer.
Association Rate Constant: 2.1 x 106 1/Ms
Determination Method: SPR analysis (ProteOn XPR36)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: HAVCR1
Gene ID: 26762
Uniprot ID: HAVR1_HUMAN
Immunogen: Human kidney injury molecule 1
Tissue Specificity Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Post Translational Modifications Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis.
Function Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry.
Protein Name Hepatitis A Virus Cellular Receptor 1
Havcr-1
Kidney Injury Molecule 1
Kim-1
T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1
Timd-1
T-Cell Immunoglobulin Mucin Receptor 1
Tim
Tim-1
T-Cell Membrane Protein 1
Cd Antigen Cd365
Database Links Reactome: R-HSA-9694614
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Hepatitis A Virus Cellular Receptor 1 antibody
Anti-Havcr-1 antibody
Anti-Kidney Injury Molecule 1 antibody
Anti-Kim-1 antibody
Anti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibody
Anti-Timd-1 antibody
Anti-T-Cell Immunoglobulin Mucin Receptor 1 antibody
Anti-Tim antibody
Anti-Tim-1 antibody
Anti-T-Cell Membrane Protein 1 antibody
Anti-Cd Antigen Cd365 antibody
Anti-HAVCR1 antibody
Anti-KIM1 antibody
Anti-TIM1 antibody
Anti-TIMD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance