Anti-KIF7 antibody (1044-1343) (STJ117776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIF7 (1044-1343) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF7 |
| Gene ID | 374654 |
| Uniprot ID | KIF7_HUMAN |
| Immunogen Region | 1044-1343 |
| Immunogen Sequence | QLDEAIEALDAAIEYKNEAI TCRQRVLRASASLLSQCEMN LMAKLSYLSSSETRALLCKY FDKVVTLREEQHQQQIAFSE LEMQLEEQQRLVYWLEVALE RQRLEMDRQLTLQQKEHEQN MQLLLQQSRDHLGEGLADSR RQYEARIQALEKELGRYMWI NQELKQKLGGVNAVGHSRGG EKRSLCSEGRQAPGNEDELH LAPELLWLSPLTEGAPRTRE ETRDLVHAPLPLTWKRSSL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1044-1343 of human KIF7 (NP_940927.2). |
Additional Info
| Tissue Specificity | Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. |
| Post Translational Modifications | Polyubiquitinated by UBR3. |
| Function | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development. |
| Protein Name | Kinesin-Like Protein Kif7 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5632684 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyLocalizes To The Cilium Tip |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif7 antibodyAnti-KIF7 antibodyAnti-UNQ340 antibodyAnti-PRO539 antibody |
Information sourced from Uniprot.org