| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KIF5B (650-770) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:100IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIF5B |
| Gene ID: |
3799 |
| Uniprot ID: |
KINH_HUMAN |
| Immunogen Region: |
650-770 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 650-770 of human KIF5B (NP_004512.1). |
| Immunogen Sequence: |
LQNVEQKKRQLEESVDALSE ELVQLRAQEKVHEMEKEHLN KVQTANEVKQAVEQQIQSHR ETHQKQISSLRDEVEAKAKL ITDLQDQNQKMMLEQERLRV EHEKLKATDQEKSRKLHELT V |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. |
| Protein Name | Kinesin-1 Heavy ChainConventional Kinesin Heavy ChainUbiquitous Kinesin Heavy ChainUkhc |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-264876Reactome: R-HSA-5625970Reactome: R-HSA-6811434Reactome: R-HSA-9725370Reactome: R-HSA-9725371Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonCytolytic Granule MembraneLysosome MembranePeripheral Membrane ProteinCytoplasmic SideUniformly Distributed Between Soma And Neurites In Hippocampal Neurons |
| Alternative Antibody Names | Anti-Kinesin-1 Heavy Chain antibodyAnti-Conventional Kinesin Heavy Chain antibodyAnti-Ubiquitous Kinesin Heavy Chain antibodyAnti-Ukhc antibodyAnti-KIF5B antibodyAnti-KNS antibodyAnti-KNS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
