Anti-KIF5B antibody (650-770) (STJ117479)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIF5B (650-770) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:100IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF5B |
| Gene ID | 3799 |
| Uniprot ID | KINH_HUMAN |
| Immunogen Region | 650-770 |
| Immunogen Sequence | LQNVEQKKRQLEESVDALSE ELVQLRAQEKVHEMEKEHLN KVQTANEVKQAVEQQIQSHR ETHQKQISSLRDEVEAKAKL ITDLQDQNQKMMLEQERLRV EHEKLKATDQEKSRKLHELT V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 650-770 of human KIF5B (NP_004512.1). |
Additional Info
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. |
| Protein Name | Kinesin-1 Heavy ChainConventional Kinesin Heavy ChainUbiquitous Kinesin Heavy ChainUkhc |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-264876Reactome: R-HSA-5625970Reactome: R-HSA-6811434Reactome: R-HSA-9725370Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonCytolytic Granule MembraneLysosome MembranePeripheral Membrane ProteinCytoplasmic SideUniformly Distributed Between Soma And Neurites In Hippocampal Neurons |
| Alternative Antibody Names | Anti-Kinesin-1 Heavy Chain antibodyAnti-Conventional Kinesin Heavy Chain antibodyAnti-Ubiquitous Kinesin Heavy Chain antibodyAnti-Ukhc antibodyAnti-KIF5B antibodyAnti-KNS antibodyAnti-KNS1 antibody |
Information sourced from Uniprot.org