Anti-KIF5A antibody (933-1032) (STJ24310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIF5A (933-1032) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:3000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF5A |
| Gene ID | 3798 |
| Uniprot ID | KIF5A_HUMAN |
| Immunogen Region | 933-1032 |
| Immunogen Sequence | TNPYGTRSPECISYTNSLFQ NYQNLYLQATPSSTSDMYFA NSCTSSGATSSGGPLASYQK ANMDNGNATDINDNRSDLPC GYEAEDQAKLFPLHQETAAS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 933-1032 of human KIF5A (NP_004975.2). |
Additional Info
| Tissue Specificity | Distributed throughout the CNS but is highly enriched in subsets of neurons. |
| Function | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. |
| Protein Name | Kinesin Heavy Chain Isoform 5aKinesin Heavy Chain Neuron-Specific 1Neuronal Kinesin Heavy ChainNkhc |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-264876Reactome: R-HSA-5625970Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonPerikaryonConcentrated In The Cell Body Of The NeuronsParticularly In The Perinuclear Region |
| Alternative Antibody Names | Anti-Kinesin Heavy Chain Isoform 5a antibodyAnti-Kinesin Heavy Chain Neuron-Specific 1 antibodyAnti-Neuronal Kinesin Heavy Chain antibodyAnti-Nkhc antibodyAnti-KIF5A antibodyAnti-NKHC1 antibody |
Information sourced from Uniprot.org