Anti-KIF20A antibody (591-890) (STJ117572)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIF20A (591-890) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF20A |
| Gene ID | 10112 |
| Uniprot ID | KI20A_HUMAN |
| Immunogen Region | 591-890 |
| Immunogen Sequence | EICNEMVEQMQQREQWCSEH LDTQKELLEEMYEEKLNILK ESLTSFYQEEIQERDEKIEE LEALLQEARQQSVAHQQSGS ELALRRSQRLAASASTQQLQ EVKAKLQQCKAELNSTTEEL HKYQKMLEPPPSAKPFTIDV DKKLEEGQKNIRLLRTELQK LGESLQSAERACCHSTGAGK LRQALTTCDDILIKQDQTLA ELQNNMVLVKLDLRKKAACI AEQYHTVLKLQGQVSAKKR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 591-890 of human KIF20A (NP_005724.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle. |
| Function | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. |
| Protein Name | Kinesin-Like Protein Kif20aGg10_2Mitotic Kinesin-Like Protein 2Mklp2Rab6-Interacting Kinesin-Like ProteinRabkinesin-6 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-68884Reactome: R-HSA-983189 |
| Cellular Localisation | Golgi ApparatusCytoplasmCytoskeletonSpindleLocalizes To The Spindle Midzone During Anaphase And Telophase |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif20a antibodyAnti-Gg10_2 antibodyAnti-Mitotic Kinesin-Like Protein 2 antibodyAnti-Mklp2 antibodyAnti-Rab6-Interacting Kinesin-Like Protein antibodyAnti-Rabkinesin-6 antibodyAnti-KIF20A antibodyAnti-MKLP2 antibodyAnti-RAB6KIFL antibody |
Information sourced from Uniprot.org