• Immunohistochemistry of rat muscle with Anti-KIF14 primary antibody (STJ501537) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-KIF14 antibody (850-960) (STJ501537)

SKU:
STJ501537-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KIF14 (850-960) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.56 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
ICC: 1:100
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: KIF14
Gene ID: 9928
Uniprot ID: KIF14_HUMAN
Immunogen Region: 850-960
Immunogen: Synthetic peptide taken within amino acid region 850-960 on human KIF14 protein.
Function Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division. Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules.
Protein Name Kinesin-Like Protein Kif14
Database Links Reactome: R-HSA-5625900
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle
Midbody
Nuclear Localization Observed During Interphase
Nuclear Localization Triggered By Entry Into Mitosis
Cytoplasmic In Interphase
Cytoplasmic In Metaphase Cells
From Prophase To Metaphase
Accumulates At The Developing Spindle Poles And Their Associated Microtubules
During Anaphase
Accumulates At The Spindle Midzone
Localization To The Central Spindle And Midbody During Anaphase Is Dependent Upon Prc1 And Cit Presence
In Cells Ready To Undergo Abscission
Concentrates At The Contractile Ring
Alternative Antibody Names Anti-Kinesin-Like Protein Kif14 antibody
Anti-KIF14 antibody
Anti-KIAA0042 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance