| Tissue Specificity | Detected in neural and non-neural cell lines. |
| Post Translational Modifications | Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function. |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
| Protein Name | Far Upstream Element-Binding Protein 2Fuse-Binding Protein 2Kh Type-Splicing Regulatory ProteinKsrpP75 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-450604 |
| Cellular Localisation | NucleusCytoplasmA Small Proportion Is Also Found In The Cytoplasm Of Neuronal Cell Bodies And Dendrites |
| Alternative Antibody Names | Anti-Far Upstream Element-Binding Protein 2 antibodyAnti-Fuse-Binding Protein 2 antibodyAnti-Kh Type-Splicing Regulatory Protein antibodyAnti-Ksrp antibodyAnti-P75 antibodyAnti-KHSRP antibodyAnti-FUBP2 antibody |
Information sourced from Uniprot.org
