![Anti-Keratin 17 antibody [E3] (STJ16101023)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149739/302481/STJ16101023_1__56682.1646940659.jpg?c=1 "Anti-Keratin 17 antibody [E3] (STJ16101023)")
![Anti-Keratin 17 antibody [E3] (STJ16101023)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149739/302482/STJ16101023_2__02292.1646940660.jpg?c=1 "Anti-Keratin 17 antibody [E3] (STJ16101023)")
![Anti-Keratin 17 antibody [E3] (STJ16101023)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149739/302481/STJ16101023_1__56682.1646940659.jpg?c=1 "Anti-Keratin 17 antibody [E3] (STJ16101023)")
Anti-Keratin 17 antibody [E3] (STJ16101023)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenA BALB/c mouse was immunized with an intermediate filament preparation of rat colon mucosa.
General Information
| Short Description | Mouse monoclonal anti-Keratin 17 for use in FC, WB, IF and IHC in Cat, Cow, Dog, Goat, Human, Pig, Rabbit and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB/IF/IHC |
| Host | Mouse |
| Reactivity | Cat/Cow/Dog/Goat/Human/Pig/Rabbit/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | E3 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 ยตg/mL, 500 ยตg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Flow Cytometry (0.5-1.0 ยตg/million cells in 0.1 ml, fix cells in 4% PFA for 10 min, at 4ยฐC, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4ยฐC). Immunoblotting (1 ยตg/ml for 2h at RT). Immunofluorescence (0.5-1, 0 ยตg/ml). Immunohistology |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8ยฐC upon receipt. |
Target Information
| Gene Symbol | Krt17 |
| Gene ID | 287702 |
| Uniprot ID | K1C17_RAT |
| Immunogen | A BALB/c mouse was immunized with an intermediate filament preparation of rat colon mucosa. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. |
| Function | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Protein Name | Keratin - Type I Cytoskeletal 17Cytokeratin-17Ck-17Keratin-17K17Type I Keratin Ka17 |
| Database Links | Reactome: R-RNO-6805567Reactome: -RNO-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 17 antibodyAnti-Cytokeratin-17 antibodyAnti-Ck-17 antibodyAnti-Keratin-17 antibodyAnti-K17 antibodyAnti-Type I Keratin Ka17 antibodyAnti-Krt17 antibodyAnti-Ka17 antibody |
Information sourced from Uniprot.org