| Function | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. |
| Protein Name | Lysine-Specific Demethylase 7aJmjc Domain-Containing Histone Demethylation Protein 1dLysine-Specific Demethylase 7Histone H3-Dimethyl-L-Lysine9 Demethylase 7a |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-6802952 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 7a antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1d antibodyAnti-Lysine-Specific Demethylase 7 antibodyAnti-Histone H3-Dimethyl-L-Lysine9 Demethylase 7a antibodyAnti-KDM7A antibodyAnti-JHDM1D antibodyAnti-KDM7 antibodyAnti-KIAA1718 antibody |
Information sourced from Uniprot.org
