| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KDM7A (100-940) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Kdm7a |
| Gene ID: |
338523 |
| Uniprot ID: |
KDM7A_MOUSE |
| Immunogen Region: |
100-940 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-940 of mouse KDM7A (NP_001028602.2). |
| Immunogen Sequence: |
WHRHDYTEVDDGSKPVQAGT RAFVKELRSRVFPSADEIIV KMHGSQLTQRYLEKHGFDVP IMVPKLDDLGLRLPSPAFSV MDVERYVGGDKVIDVIDVAR Q |
| Function | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. |
| Protein Name | Lysine-Specific Demethylase 7aJmjc Domain-Containing Histone Demethylation Protein 1dLysine-Specific Demethylase 7Histone H3-Dimethyl-L-Lysine9 Demethylase 7a |
| Database Links | Reactome: R-MMU-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 7a antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1d antibodyAnti-Lysine-Specific Demethylase 7 antibodyAnti-Histone H3-Dimethyl-L-Lysine9 Demethylase 7a antibodyAnti-Kdm7a antibodyAnti-Jhdm1d antibodyAnti-Kdm7 antibodyAnti-Kiaa1718 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
