Anti-KDM6A antibody [SRM14988] (STJ11109718)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal KDM6A antibody for use in WB, IF-P, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF-P/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14988 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:12000-1:48000IF-P, 1:50-1:200IHC-P, 1:400-1:800ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM6A |
| Gene ID | 7403 |
| Uniprot ID | KDM6A_HUMAN |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
| Protein Name | Lysine-Specific Demethylase 6aHistone Demethylase UtxUbiquitously-Transcribed Tpr Protein On The X ChromosomeUbiquitously-Transcribed X Chromosome Tetratricopeptide Repeat ProteinHistone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5617472Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9821002Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibodyAnti-Histone Demethylase Utx antibodyAnti-Ubiquitously-Transcribed Tpr Protein On The X Chromosome antibodyAnti-Ubiquitously-Transcribed X Chromosome Tetratricopeptide Repeat Protein antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibodyAnti-KDM6A antibodyAnti-UTX antibody |
Information sourced from Uniprot.org