Anti-KDM5D antibody (STJ191878)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Lysine-specific demethylase 5D demethylase 5D for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM5D |
| Gene ID | 8284 |
| Uniprot ID | KDM5D_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | KDM5D Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes.in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. |
| Protein Name | Lysine-Specific Demethylase 5dHistocompatibility Y AntigenH-YHistone Demethylase Jarid1dJumonji/Arid Domain-Containing Protein 1dProtein SmcyHistone H3-Trimethyl-L-Lysine(4 Demethylase 5d |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5d antibodyAnti-Histocompatibility Y Antigen antibodyAnti-H-Y antibodyAnti-Histone Demethylase Jarid1d antibodyAnti-Jumonji/Arid Domain-Containing Protein 1d antibodyAnti-Protein Smcy antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d antibodyAnti-KDM5D antibodyAnti-HY antibodyAnti-HYA antibodyAnti-JARID1D antibodyAnti-KIAA0234 antibodyAnti-SMCY antibody |
Information sourced from Uniprot.org