Anti-KDM5C antibody (C-Term) (STJ98552)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenPurified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-Lysine-specific demethylase 5C demethylase 5C (C-Term) for use in WB and IF in Human, Mouse, Rat, Cow and Dog samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat/Cow/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:1000-1:2000IF 1:100-1:500 |
| Formulation | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM5C |
| Gene ID | 8242 |
| Uniprot ID | KDM5C_HUMAN |
| Immunogen | Purified recombinant human SmcX (C-terminus) protein fragments expressed in E.coli. |
| Immunogen Region | C-Term |
| Specificity | SmcX Monoclonal Antibody detects endogenous levels of SmcX protein. |
Additional Info
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. |
| Protein Name | Lysine-Specific Demethylase 5cHistone Demethylase Jarid1cJumonji/Arid Domain-Containing Protein 1cProtein SmcxProtein Xe169Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 5c antibodyAnti-Histone Demethylase Jarid1c antibodyAnti-Jumonji/Arid Domain-Containing Protein 1c antibodyAnti-Protein Smcx antibodyAnti-Protein Xe169 antibodyAnti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibodyAnti-KDM5C antibodyAnti-DXS1272E antibodyAnti-JARID1C antibodyAnti-SMCX antibodyAnti-XE169 antibody |
Information sourced from Uniprot.org