Anti-KDM4C antibody (500-520) (STJ501521)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 500-520 on human JmjC domain-containing histone demethylation protein 3C protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-KDM4C (500-520) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:2, 500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM4C |
| Gene ID | 23081 |
| Uniprot ID | KDM4C_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 500-520 on human JmjC domain-containing histone demethylation protein 3C protein. |
| Immunogen Region | 500-520 |
Additional Info
| Tissue Specificity | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4cGene Amplified In Squamous Cell Carcinoma 1 ProteinGasc-1 ProteinJmjc Domain-Containing Histone Demethylation Protein 3cJumonji Domain-Containing Protein 2cHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5625886 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4c antibodyAnti-Gene Amplified In Squamous Cell Carcinoma 1 Protein antibodyAnti-Gasc-1 Protein antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3c antibodyAnti-Jumonji Domain-Containing Protein 2c antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4c antibodyAnti-KDM4C antibodyAnti-GASC1 antibodyAnti-JHDM3C antibodyAnti-JMJD2C antibodyAnti-KIAA0780 antibody |
Information sourced from Uniprot.org