| Short Description : | Rabbit monoclonal KDM4B/JMJD2B (50-150) antibody for use in WB, IF, ICC, IP, ELISA and ChIP in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/IP/ELISA/ChIP |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KDM4B |
| Gene ID: | 23030 |
| Uniprot ID: | KDM4B_HUMAN |
| Immunogen Region: | 50-150 |
| Immunogen Sequence: | PPKEWKPRQTYDDIDDVVIP APIQQVVTGQSGLFTQYNIQ KKAMTVGEYRRLANSEKYCT PRHQDFDDLERKYWKNLTFV SPIYGADISGSLYDDDVAQW N |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KDM4B/JMJD2B (O94953). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS). |
| Protein Name | Lysine-Specific Demethylase 4bJmjc Domain-Containing Histone Demethylation Protein 3bJumonji Domain-Containing Protein 2bHistone H3-Trimethyl-L-Lysine(9 Demethylase 4b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5693565Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4b antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3b antibodyAnti-Jumonji Domain-Containing Protein 2b antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4b antibodyAnti-KDM4B antibodyAnti-JHDM3B antibodyAnti-JMJD2B antibodyAnti-KIAA0876 antibody |
Information sourced from Uniprot.org
