| Tissue Specificity | Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. |
| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd21Kcash2 ProteinPotassium Channel Tetramerization Domain-Containing Protein 21 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd21 antibodyAnti-Kcash2 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 21 antibodyAnti-KCTD21 antibody |
Information sourced from Uniprot.org
