| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Mouse/Rat/Pig/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-KCNQ5 (C-Term) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
KCNQ5 |
| Gene ID: |
56479 |
| Uniprot ID: |
KCNQ5_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_062816.2; NP_001153602.1; NP_001153604.1; NP_1153605.1; NP_001153606.1 |
| Specificity: |
This antibody is expected to cross-react with isoform 1, 2, 3, 4 and 5 (NP_062816.2; NP_001153602.1; NP_001153604.1; NP_1153605.1; NP_001153606.1). |
| Immunogen Sequence: |
ESTDALSLPHVKLK |
| Function | Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 5Kqt-Like 5Potassium Channel Subunit Alpha Kvlqt5Voltage-Gated Potassium Channel Subunit Kv7.5 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 5 antibodyAnti-Kqt-Like 5 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt5 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.5 antibodyAnti-KCNQ5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
