Anti-KCNQ3 antibody (60-120 aa) (STJ13100164)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 60-120 of mouse KCNQ3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat.
General Information
| Short Description | Rabbit polyclonal anti-KCNQ3 (60-120 aa) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNQ3 |
| Gene ID | 3786 |
| Uniprot ID | KCNQ3_HUMAN |
| Immunogen | A synthetic peptide from aa region 60-120 of mouse KCNQ3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Immunogen Region | 60-120 aa |
| Specificity | Specific for KCNQ3. |
Additional Info
| Post Translational Modifications | KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36. |
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 3Kqt-Like 3Potassium Channel Subunit Alpha Kvlqt3Voltage-Gated Potassium Channel Subunit Kv7.3 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-445095 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 3 antibodyAnti-Kqt-Like 3 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.3 antibodyAnti-KCNQ3 antibody |
Information sourced from Uniprot.org