| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNN4 (288-427) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNN4 |
| Gene ID: |
3783 |
| Uniprot ID: |
KCNN4_HUMAN |
| Immunogen Region: |
288-427 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 288-427 of human KCNN4 (NP_002241.1). |
| Immunogen Sequence: |
KLEFNKAEKHVHNFMMDIQY TKEMKESAARVLQEAWMFYK HTRRKESHAARRHQRKLLAA INAFRQVRLKHRKLREQVNS MVDISKMHMILYDLQQNLSS SHRALEKQIDTLAGKLDALT ELLSTALGPRQLPEPSQQSK |
| Tissue Specificity | Widely expressed in non-excitable tissues. |
| Post Translational Modifications | Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel. |
| Function | Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis. |
| Protein Name | Intermediate Conductance Calcium-Activated Potassium Channel Protein 4Sk4Skca 4Skca4Ikca1Ik1Kca3.1Kca4Putative Gardos Channel |
| Database Links | Reactome: R-HSA-1296052 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Intermediate Conductance Calcium-Activated Potassium Channel Protein 4 antibodyAnti-Sk4 antibodyAnti-Skca 4 antibodyAnti-Skca4 antibodyAnti-Ikca1 antibodyAnti-Ik1 antibodyAnti-Kca3.1 antibodyAnti-Kca4 antibodyAnti-Putative Gardos Channel antibodyAnti-KCNN4 antibodyAnti-IK1 antibodyAnti-IKCA1 antibodyAnti-KCA4 antibodyAnti-SK4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
