| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNN3 (250-300 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNN3 |
| Gene ID: |
3782 |
| Uniprot ID: |
KCNN3_HUMAN |
| Immunogen Region: |
250-300 aa |
| Specificity: |
Specific for KCNN3. |
| Immunogen: |
A synthetic peptide from aa region 250-300 of human KCNN3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Function | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening. The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens. Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. Isoform 3: Does not function as a small conductance calcium-activated potassium channel (Probable). Selectively suppresses endogenous KCNN3 currents, in a dominant-negative fashion by decreasing the abundance of functional channels in the plasma membrane, possibly by selectively coassembling with and sequestering native KCNN3 protein in intracellular compartments. This dominant inhibitory effect extends to other members of the SK subfamily. |
| Protein Name | Small Conductance Calcium-Activated Potassium Channel Protein 3Sk3Skca 3Skca3Kca2.3 |
| Database Links | Reactome: R-HSA-1296052 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 antibodyAnti-Sk3 antibodyAnti-Skca 3 antibodyAnti-Skca3 antibodyAnti-Kca2.3 antibodyAnti-KCNN3 antibodyAnti-K3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
