Anti-KCNMB3 antibody (STJ190627)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Calcium-activated potassium channel subunit beta-3beta-3 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNMB3 |
| Gene ID | 27094 |
| Uniprot ID | KCMB3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | KCMB3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. The extracellular domain contains disulfide bond essential for the gating mechanism. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-3Bk Channel Subunit Beta-3Bkbeta3Hbeta3Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3Charybdotoxin Receptor Subunit Beta-3K(Vcabeta-3Maxi K Channel Subunit Beta-3Slo-Beta-3 |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Beta-3 antibodyAnti-Bk Channel Subunit Beta-3 antibodyAnti-Bkbeta3 antibodyAnti-Hbeta3 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-3 antibodyAnti-Charybdotoxin Receptor Subunit Beta-3 antibodyAnti-K(Vcabeta-3 antibodyAnti-Maxi K Channel Subunit Beta-3 antibodyAnti-Slo-Beta-3 antibodyAnti-KCNMB3 antibodyAnti-KCNMB2 antibodyAnti-KCNMBL antibody |
Information sourced from Uniprot.org