Anti-KCNMB2 antibody (68-194) (STJ112315)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCNMB2 (68-194) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNMB2 |
| Gene ID | 10242 |
| Uniprot ID | KCMB2_HUMAN |
| Immunogen Region | 68-194 |
| Immunogen Sequence | TLLRSYMQSVWTEESQCTLL NASITETFNCSFSCGPDCWK LSQYPCLQVYVNLTSSGEKL LLYHTEETIKINQKCSYIPK CGKNFEESMSLVNVVMENFR KYQHFSCYSDPEGNQKSVIL TKLYSSN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1). |
Additional Info
| Tissue Specificity | Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-2Bk Channel Subunit Beta-2Bkbeta2Hbeta2Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2Charybdotoxin Receptor Subunit Beta-2Hbeta3K(Vcabeta-2Maxi K Channel Subunit Beta-2Slo-Beta-2 |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Beta-2 antibodyAnti-Bk Channel Subunit Beta-2 antibodyAnti-Bkbeta2 antibodyAnti-Hbeta2 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2 antibodyAnti-Charybdotoxin Receptor Subunit Beta-2 antibodyAnti-Hbeta3 antibodyAnti-K(Vcabeta-2 antibodyAnti-Maxi K Channel Subunit Beta-2 antibodyAnti-Slo-Beta-2 antibodyAnti-KCNMB2 antibody |
Information sourced from Uniprot.org