| Short Description : | Rabbit polyclonal KCNJ3 (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCNJ3 |
| Gene ID: | 3760 |
| Uniprot ID: | KCNJ3_HUMAN |
| Immunogen Region: | 50-150 |
| Immunogen Sequence: | NGRCNVQHGNLGSETSRYLS DLFTTLVDLKWRWNLFIFIL TYTVAWLFMASMWWVIAYTR GDLNKAHVGNYTPCVANVYN FPSAFLFFIETEATIGYGYR Y |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ3 (NP_002230.1). |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. This receptor plays a crucial role in regulating the heartbeat. |
| Protein Name | G Protein-Activated Inward Rectifier Potassium Channel 1Girk-1Inward Rectifier K(+ Channel Kir3.1Potassium Channel - Inwardly Rectifying Subfamily J Member 3 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G Protein-Activated Inward Rectifier Potassium Channel 1 antibodyAnti-Girk-1 antibodyAnti-Inward Rectifier K(+ Channel Kir3.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 3 antibodyAnti-KCNJ3 antibodyAnti-GIRK1 antibody |
Information sourced from Uniprot.org
