Anti-KCNJ13 antibody (200-250 aa) (STJ13101294)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 200-250 of human KCNJ13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with rat and mouse sequences.
General Information
| Short Description | Rabbit polyclonal anti-KCNJ13 (200-250 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A concentration of 10-50 ยตg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNJ13 |
| Gene ID | 3769 |
| Uniprot ID | KCJ13_HUMAN |
| Immunogen | A synthetic peptide from aa region 200-250 of human KCNJ13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with rat and mouse sequences. |
| Immunogen Region | 200-250 aa |
| Specificity | Specific for KCNJ13. |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Protein Name | Inward Rectifier Potassium Channel 13Inward Rectifier K(+ Channel Kir7.1Potassium Channel - Inwardly Rectifying Subfamily J Member 13 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneLocalized At The Retinal Pigmented Epithelium (Rpe) Apical Microvilli |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 13 antibodyAnti-Inward Rectifier K(+ Channel Kir7.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 13 antibodyAnti-KCNJ13 antibody |
Information sourced from Uniprot.org