| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNJ12 (354-433) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNJ12 |
| Gene ID: |
3768 |
| Uniprot ID: |
KCJ12_HUMAN |
| Immunogen Region: |
354-433 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 354-433 of human KCNJ12 (NP_066292.2). |
| Immunogen Sequence: |
TPRCSAKDLVENKFLLPSAN SFCYENELAFLSRDEEDEAD GDQDGRSRDGLSPQARHDFD RLQAGGGVLEQRPYRRESEI |
| Function | Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 12Inward Rectifier K(+ Channel Kir2.2Irk-2Inward Rectifier K(+ Channel Kir2.2vPotassium Channel - Inwardly Rectifying Subfamily J Member 12 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296053Reactome: R-HSA-5576886Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 12 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2 antibodyAnti-Irk-2 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2v antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 12 antibodyAnti-KCNJ12 antibodyAnti-IRK2 antibodyAnti-KCNJN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
