Anti-KCNJ12 antibody (354-433) (STJ116587)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCNJ12 (354-433) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ12 |
| Gene ID | 3768 |
| Uniprot ID | KCJ12_HUMAN |
| Immunogen Region | 354-433 |
| Immunogen Sequence | TPRCSAKDLVENKFLLPSAN SFCYENELAFLSRDEEDEAD GDQDGRSRDGLSPQARHDFD RLQAGGGVLEQRPYRRESEI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 354-433 of human KCNJ12 (NP_066292.2). |
Additional Info
| Function | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 12Inward Rectifier K(+ Channel Kir2.2Irk-2Inward Rectifier K(+ Channel Kir2.2vPotassium Channel - Inwardly Rectifying Subfamily J Member 12 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296053Reactome: R-HSA-5576886Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaT-Tubule |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 12 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2 antibodyAnti-Irk-2 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2v antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 12 antibodyAnti-KCNJ12 antibodyAnti-IRK2 antibodyAnti-KCNJN1 antibody |
Information sourced from Uniprot.org