| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATP-sensitive inward rectifier potassium channel 10 channel Kir1.2 (160-240 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNJ10 |
| Gene ID: |
3766 |
| Uniprot ID: |
KCJ10_HUMAN |
| Immunogen Region: |
160-240 aa |
| Specificity: |
This antibody detects endogenous levels of Human, Rat, Mouse Kir4.1 |
| Immunogen: |
Synthesized peptide derived from the human Kir4.1 at the amino acid range 160-240 |
| Function | May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 10Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1Inward Rectifier K(+ Channel Kir1.2Potassium Channel - Inwardly Rectifying Subfamily J Member 10 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296067Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIn Kidney Distal Convoluted TubulesLocated In The Basolateral Membrane Where It Colocalizes With Kcnj16 |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 10 antibodyAnti-Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1 antibodyAnti-Inward Rectifier K(+ Channel Kir1.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 10 antibodyAnti-KCNJ10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
