| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNJ1 |
| Gene ID: |
3758 |
| Uniprot ID: |
KCNJ1_HUMAN |
| Immunogen Region: |
50-150 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ1 (NP_000211.1). |
| Immunogen Sequence: |
NIEFGNVEAQSRFIFFVDIW TTVLDLKWRYKMTIFITAFL GSWFFFGLLWYAVAYIHKDL PEFHPSANHTPCVENINGLT SAFLFSLETQVTIGYGFRCV T |
| Tissue Specificity | In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. |
| Post Translational Modifications | Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 1Atp-Regulated Potassium Channel Rom-KInward Rectifier K(+ Channel Kir1.1Potassium Channel - Inwardly Rectifying Subfamily J Member 1 |
| Database Links | Reactome: R-HSA-1296067 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPhosphorylation At Ser-44 By Sgk1 Is Necessary For Its Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 1 antibodyAnti-Atp-Regulated Potassium Channel Rom-K antibodyAnti-Inward Rectifier K(+ Channel Kir1.1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 1 antibodyAnti-KCNJ1 antibodyAnti-ROMK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
