| Host: |
Goat |
| Applications: |
Pep-ELISA/WB-Trf |
| Reactivity: |
Human/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-KCNIP3 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-Recommended concentration, 1-3µg/mlELISA-antibody detection limit dilution 1:1000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
KCNIP3 |
| Gene ID: |
30818 |
| Uniprot ID: |
CSEN_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_038462.1 |
| Specificity: |
This antibody is expected to recognize isoform 1 (NP_038462.1) only. |
| Immunogen Sequence: |
SLLGDLGHTPLS |
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. Phosphorylation at Ser-63 inhibits cleavage by CASP3. |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. |
| Protein Name | CalsenilinA-Type Potassium Channel Modulatory Protein 3Dre-Antagonist ModulatorDreamKv Channel-Interacting Protein 3Kchip3 |
| Database Links | Reactome: R-HSA-5576894Reactome: R-HSA-9768777 |
| Cellular Localisation | CytoplasmCell MembraneLipid-AnchorEndoplasmic ReticulumGolgi ApparatusNucleusAlso Membrane-BoundAssociated With The Plasma MembraneIn The Presence Of Psen2 Associated With The Endoplasmic Reticulum And GolgiThe Sumoylated Form Is Present Only In The Nucleus |
| Alternative Antibody Names | Anti-Calsenilin antibodyAnti-A-Type Potassium Channel Modulatory Protein 3 antibodyAnti-Dre-Antagonist Modulator antibodyAnti-Dream antibodyAnti-Kv Channel-Interacting Protein 3 antibodyAnti-Kchip3 antibodyAnti-KCNIP3 antibodyAnti-CSEN antibodyAnti-DREAM antibodyAnti-KCHIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
