Anti-KCNH3 antibody (470-550 aa) (STJ93822)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from KCNH3 at the amino acid range 470-550
General Information
| Short Description | Rabbit polyclonal anti-Potassium voltage-gated channel subfamily H member 3 (470-550 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNH3 |
| Gene ID | 23416 |
| Uniprot ID | KCNH3_HUMAN |
| Immunogen | Synthesized peptide derived from KCNH3 at the amino acid range 470-550 |
| Immunogen Region | 470-550 aa |
| Specificity | KCNH3 Polyclonal Antibody detects endogenous levels of KCNH3 protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity. |
| Function | Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel. Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism. Exhibits a rapid recovery from inactivation. |
| Protein Name | Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3Brain-Specific Eag-Like Channel 1Bec1Ether-A-Go-Go-Like Potassium Channel 2Elk Channel 2Elk2Potassium Voltage-Gated Channel Subfamily H Member 3Voltage-Gated Potassium Channel Subunit Kv12.2 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinExpression On The Cell Membrane Requires At Least One Of The Three Glycosylation Sites To Carry A Sugar Chain Irrespective Of Their Positions |
| Alternative Antibody Names | Anti-Voltage-Gated Inwardly Rectifying Potassium Channel Kcnh3 antibodyAnti-Brain-Specific Eag-Like Channel 1 antibodyAnti-Bec1 antibodyAnti-Ether-A-Go-Go-Like Potassium Channel 2 antibodyAnti-Elk Channel 2 antibodyAnti-Elk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv12.2 antibodyAnti-KCNH3 antibodyAnti-KIAA1282 antibody |
Information sourced from Uniprot.org