• Immunohistochemistry analysis of KCNH2 in paraffin-embedded human breast cancer using KCNH2 Rabbit polyclonal antibody (STJ24293) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of KCNH2 in paraffin-embedded human colon carcinoma using KCNH2 Rabbit polyclonal antibody (STJ24293) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of KCNH2 in paraffin-embedded human lung cancer using KCNH2 Rabbit polyclonal antibody (STJ24293) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using KCNH2 Rabbit polyclonal antibody (STJ24293) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.

Anti-KCNH2 antibody (850-950) (STJ24293)

SKU:
STJ24293

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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KCNH2 (850-950) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNH2
Gene ID: 3757
Uniprot ID: KCNH2_HUMAN
Immunogen Region: 850-950
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNH2 (NP_000229.1).
Immunogen Sequence: DHFWSSLEITFNLRDTNMIP GSPGSTELEGGFSRQRKRKL SFRRRTDKDTEQPGEVSALG PGRAGAGPSSRGRPGGPWGE SPSSGPSSPESSEDEGPGRS S
Tissue Specificity Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Post Translational Modifications Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
Function Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform A-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Protein Name Potassium Voltage-Gated Channel Subfamily H Member 2
Eag Homolog
Ether-A-Go-Go-Related Gene Potassium Channel 1
Erg-1
Eag-Related Protein 1
Ether-A-Go-Go-Related Protein 1
H-Erg
Herg-1
Herg1
Voltage-Gated Potassium Channel Subunit Kv11.1
Database Links Reactome: R-HSA-1296072
Reactome: R-HSA-5576890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Potassium Voltage-Gated Channel Subfamily H Member 2 antibody
Anti-Eag Homolog antibody
Anti-Ether-A-Go-Go-Related Gene Potassium Channel 1 antibody
Anti-Erg-1 antibody
Anti-Eag-Related Protein 1 antibody
Anti-Ether-A-Go-Go-Related Protein 1 antibody
Anti-H-Erg antibody
Anti-Herg-1 antibody
Anti-Herg1 antibody
Anti-Voltage-Gated Potassium Channel Subunit Kv11.1 antibody
Anti-KCNH2 antibody
Anti-ERG antibody
Anti-ERG1 antibody
Anti-HERG antibody

Information sourced from Uniprot.org

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