Anti-KCNH1/EAG1 antibody [SAA1808] (STJA0020236)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1808 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | KCNH1 |
| Gene ID | 3756 |
| Uniprot ID | KCNH1_HUMAN |
Additional Info
| Post Translational Modifications | Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs). |
| Protein Name | Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1Ether-A-Go-Go Potassium Channel 1Eag Channel 1H-EagHeag1Potassium Voltage-Gated Channel Subfamily H Member 1Voltage-Gated Potassium Channel Subunit Kv10.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneCell ProjectionDendriteAxonPresynaptic Cell MembranePerikaryonPostsynaptic Density MembraneEarly Endosome MembranePerinuclear Kcnh1 Is Located To Npc-Free Islands |
| Alternative Antibody Names | Anti-Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1 antibodyAnti-Ether-A-Go-Go Potassium Channel 1 antibodyAnti-Eag Channel 1 antibodyAnti-H-Eag antibodyAnti-Heag1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv10.1 antibodyAnti-KCNH1 antibodyAnti-EAG antibodyAnti-EAG1 antibody |
Information sourced from Uniprot.org