Anti-KCNH1 antibody (C-Term) (STJ13101618)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal of human KCNH1conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNH1 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNH1 |
| Gene ID | 3756 |
| Uniprot ID | KCNH1_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal of human KCNH1conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for KCNH1. |
Additional Info
| Post Translational Modifications | Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs). |
| Protein Name | Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1Ether-A-Go-Go Potassium Channel 1Eag Channel 1H-EagHeag1Potassium Voltage-Gated Channel Subfamily H Member 1Voltage-Gated Potassium Channel Subunit Kv10.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneCell ProjectionDendriteAxonPresynaptic Cell MembranePerikaryonPostsynaptic Density MembraneEarly Endosome MembranePerinuclear Kcnh1 Is Located To Npc-Free Islands |
| Alternative Antibody Names | Anti-Voltage-Gated Delayed Rectifier Potassium Channel Kcnh1 antibodyAnti-Ether-A-Go-Go Potassium Channel 1 antibodyAnti-Eag Channel 1 antibodyAnti-H-Eag antibodyAnti-Heag1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv10.1 antibodyAnti-KCNH1 antibodyAnti-EAG antibodyAnti-EAG1 antibody |
Information sourced from Uniprot.org