Anti-KCNE3 antibody (30-110 aa) (STJ191186)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 30-110
General Information
| Short Description | Rabbit polyclonal anti-Potassium voltage-gated channel subfamily E member 3 (30-110 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNE3 |
| Gene ID | 10008 |
| Uniprot ID | KCNE3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 30-110 |
| Immunogen Region | 30-110 aa |
| Specificity | KCNE3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 3Mink-Related Peptide 2Mirp2Minimum Potassium Ion Channel-Related Peptide 2Potassium Channel Subunit Beta Mirp2 |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionDendriteMembrane RaftColocalizes With Kcnb1 At High-Density Somatodendritic Clusters On The Surface Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 3 antibodyAnti-Mink-Related Peptide 2 antibodyAnti-Mirp2 antibodyAnti-Minimum Potassium Ion Channel-Related Peptide 2 antibodyAnti-Potassium Channel Subunit Beta Mirp2 antibodyAnti-KCNE3 antibody |
Information sourced from Uniprot.org