Anti-KCNE2 antibody (STJ13101615)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the cytoplasmic domain of human KCNE2 (Potassium voltage-gated channel subfamily E member 2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNE2 for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNE2 |
| Gene ID | 9992 |
| Uniprot ID | KCNE2_HUMAN |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human KCNE2 (Potassium voltage-gated channel subfamily E member 2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Specificity | Specific for KCNE2. |
Additional Info
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart. May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current. May associate with HCN1 and HCN2 channel subunits to increase potassium current. Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 2Mink-Related Peptide 1Mirp1Minimum Potassium Ion Channel-Related Peptide 1Potassium Channel Subunit Beta Mirp1 |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinApical Cell MembraneSingle-Pass Membrane ProteinColocalizes With Kcnb1 At The Plasma Membrane |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 2 antibodyAnti-Mink-Related Peptide 1 antibodyAnti-Mirp1 antibodyAnti-Minimum Potassium Ion Channel-Related Peptide 1 antibodyAnti-Potassium Channel Subunit Beta Mirp1 antibodyAnti-KCNE2 antibody |
Information sourced from Uniprot.org