| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily D member 3 (91-141) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCND3 |
| Gene ID: |
3752 |
| Uniprot ID: |
KCND3_HUMAN |
| Immunogen Region: |
91-141 |
| Specificity: |
This antibody detects endogenous levels of human KCND3 |
| Immunogen: |
Synthesized peptide derived from human KCND3 AA range: 91-141 |
| Post Translational Modifications | Regulated through phosphorylation at Ser-569 by CaMK2D. |
| Function | Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd3Potassium Voltage-Gated Channel Subfamily D Member 3Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaCell ProjectionDendriteInteraction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd3 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibodyAnti-KCND3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
