Anti-KCND3 antibody (4th Cytoplasmic Domain) (STJ13101678)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from 4th cytoplasmic domain of mouse KCND3 (Kv4.3) conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCND3 (4th Cytoplasmic Domain) for use in IHC and WB in Mouse, Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Kcnd3 |
| Gene ID | 56543 |
| Uniprot ID | KCND3_MOUSE |
| Immunogen | A synthetic peptide from 4th cytoplasmic domain of mouse KCND3 (Kv4.3) conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 4th Cytoplasmic Domain |
| Specificity | Specific for KCND3. |
Additional Info
| Function | Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd3Potassium Voltage-Gated Channel Subfamily D Member 3Voltage-Gated Potassium Channel Subunit Kv4.3 |
| Database Links | Reactome: R-MMU-1296072Reactome: -MMU-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaCell ProjectionDendriteInteraction With Palmitoylated Kcnip2 And Kcnip3 Enhances Cell Surface Expression |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd3 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.3 antibodyAnti-Kcnd3 antibody |
Information sourced from Uniprot.org