Anti-KCND1 antibody (558-607 aa) (STJ93878)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KCND1 at the amino acid range 558-607
General Information
| Short Description | Rabbit polyclonal anti-Potassium voltage-gated channel subfamily D member 1 (558-607 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCND1 |
| Gene ID | 3750 |
| Uniprot ID | KCND1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KCND1 at the amino acid range 558-607 |
| Immunogen Region | 558-607 aa |
| Specificity | KV4.1 Polyclonal Antibody detects endogenous levels of KV4.1 protein. |
Additional Info
| Function | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain. Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction. The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating. |
| Protein Name | A-Type Voltage-Gated Potassium Channel Kcnd1Potassium Voltage-Gated Channel Subfamily D Member 1Shal-Type Potassium Channel Kcnd1Voltage-Gated Potassium Channel Subunit Kv4.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576894 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-A-Type Voltage-Gated Potassium Channel Kcnd1 antibodyAnti-Potassium Voltage-Gated Channel Subfamily D Member 1 antibodyAnti-Shal-Type Potassium Channel Kcnd1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4.1 antibodyAnti-KCND1 antibody |
Information sourced from Uniprot.org