Anti-KCNC3/Kv3.3 antibody (317-328) (STJ72711)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-KCNC3/Kv3.3 (317-328) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 80kDa band observed in Mouse and Rat Brain lysates (calculated MW of 81.9kDa according to Mouse NP_032448.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNC3 |
| Gene ID | 3748 |
| Uniprot ID | KCNC3_HUMAN |
| Accession Number | NP_004968.2 |
| Immunogen Region | 317-328 |
| Immunogen Sequence | HISNKTVTQASP |
Additional Info
| Function | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics. It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis. Required for normal motor function. Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc3KshiiidPotassium Voltage-Gated Channel Subfamily C Member 3Voltage-Gated Potassium Channel Subunit Kv3.3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresynaptic Cell MembranePerikaryonCell ProjectionAxonDendriteDendritic Spine MembraneCytoplasmCell CortexCytoskeletonDetected On Purkinje Cell Dendritic SpinesPositioned Perisynaptically But Also In Extrasynaptic Positions Along The Spine MembranesDetected At Presynaptic Calices Of HeldColocalizes With The Cortical Actin Cytoskeleton And The Arp2/3 Complex |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc3 antibodyAnti-Kshiiid antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.3 antibodyAnti-KCNC3 antibody |
Information sourced from Uniprot.org