Anti-KCNC1 antibody (190-270 aa) (STJ93875)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from KV3.1 at the amino acid range 190-270
General Information
| Short Description | Rabbit polyclonal anti-Potassium voltage-gated channel subfamily C member 1 (190-270 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNC1 |
| Gene ID | 3746 |
| Uniprot ID | KCNC1_HUMAN |
| Immunogen | Synthesized peptide derived from KV3.1 at the amino acid range 190-270 |
| Immunogen Region | 190-270 aa |
| Specificity | KV3.1 Polyclonal Antibody detects endogenous levels of KV3.1 protein. |
Additional Info
| Function | Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient. The mechanism is time-dependent and inactivation is slow. Plays an important role in the rapid repolarization of fast-firing brain neurons. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc1Ngk2Potassium Voltage-Gated Channel Subfamily C Member 1Voltage-Gated Potassium Channel Subunit Kv3.1Voltage-Gated Potassium Channel Subunit Kv4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonPresynaptic Cell MembraneLocalizes In Parallel Fiber MembranesDistributed On The Perisynaptic And Extrasynaptic Membranes Away From The Active Zones |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc1 antibodyAnti-Ngk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4 antibodyAnti-KCNC1 antibody |
Information sourced from Uniprot.org