| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-gated potassium channel subunit beta-2 channel subunit beta-2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNAB2 |
| Gene ID: |
8514 |
| Uniprot ID: |
KCAB2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of KCNAB2 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human KCNAB2 |
| Post Translational Modifications | Phosphorylated by PRKCZ.may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. |
| Function | Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro). |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-2K(+ Channel Subunit Beta-2Kv-Beta-2Hkvbeta2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionAxonSynapseSynaptosomeCytoskeletonRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha SubunitsAssociates With Microtubules When Unphosphorylated |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-2 antibodyAnti-K(+ Channel Subunit Beta-2 antibodyAnti-Kv-Beta-2 antibodyAnti-Hkvbeta2 antibodyAnti-KCNAB2 antibodyAnti-KCNA2B antibodyAnti-KCNK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
