| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNAB2 (1-40) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNAB2 |
| Gene ID: |
8514 |
| Uniprot ID: |
KCAB2_HUMAN |
| Immunogen Region: |
1-40 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1). |
| Immunogen Sequence: |
MYPESTTGSPARLSLRQTGS PGMIYSTRYGSPKRQLQFYR |
| Tissue Specificity | Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region. Detected in hippocampus (at protein level). Detected in hippocampus. |
| Post Translational Modifications | Phosphorylated by PRKCZ.may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1. |
| Function | Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5. Enhances KCNB2 channel activity. Binds NADPH and has NADPH-dependent aldoketoreductase activity. Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro). |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-2K(+ Channel Subunit Beta-2Kv-Beta-2Hkvbeta2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionAxonSynapseSynaptosomeCytoskeletonRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha SubunitsAssociates With Microtubules When Unphosphorylated |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-2 antibodyAnti-K(+ Channel Subunit Beta-2 antibodyAnti-Kv-Beta-2 antibodyAnti-Hkvbeta2 antibodyAnti-KCNAB2 antibodyAnti-KCNA2B antibodyAnti-KCNK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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