Anti-KBTBD8 antibody (50-280) (STJ11100464)

Name: Anti-KBTBD8 antibody (50-280) (STJ11100464)
SKU: STJ11100464
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11100464

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Short Description	Rabbit polyclonal KBTBD8 (50-280) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	KBTBD8
Gene ID	84541
Uniprot ID	KBTB8_HUMAN
Immunogen Region	50-280
Immunogen Sequence	DIVVEVDHGKTFSCHRNVLA AISPYFRSMFTSGLTESTQK EVRIVGVEAESMDLVLNYAY TSRVILTEANVQALFTAASI FQIPSIQDQCAKYMISHLDP QNSIGVFIFADHYGHQELGD RSKEYIRKKFLCVTKEQEFL QLTKDQLISILDSDDLNVDR EEHVYESIIRWFEHEQNERE VHLPEIFAKCIRFPLMEDTF IEKIPPQFAQAIAKSCVEKG PSNTNGCTQRL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 50-280 of human KBTBD8 (NP_115894.2).

Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Protein Name	Kelch Repeat And Btb Domain-Containing Protein 8 T-Cell Activation Kelch Repeat Protein Ta-Krp
Database Links	Reactome: R-HSA-8951664 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Cytoskeleton Spindle Golgi Apparatus Translocates To The Spindle Apparatus During Mitosis
Alternative Antibody Names	Anti-Kelch Repeat And Btb Domain-Containing Protein 8 antibody Anti-T-Cell Activation Kelch Repeat Protein antibody Anti-Ta-Krp antibody Anti-KBTBD8 antibody Anti-KIAA1842 antibody Anti-TAKRP antibody

Information sourced from Uniprot.org